Faculty
Jelica Gluhak-Heinrich, Ph.D.
Instructor Research
Department of Orthodontics
University of Texas Health Science Center at San
Antonio
Dental School
E-Mail: hatch@uthscsa.edu
Office: 4.600U
Phone: (210) 567-3509
Dr. Heinrich is a Research Instructor in the department of Orthodontics. She received her Ph.D. in Chemistry in 1994 from the University of Zagreb, Croatia. She completed postdoctoral training in area of Developmental Biology at the State University of Connecticut Health Science Center at Farmington. She has been on the faculty of the UTHCSA since 1996. In the department of Orthodontics, Dr Heinrich activities include participation in the research of bone remodeling. Her primary research interest is regulation of genes for bone cells (osteoblast, osteocytes and osteoclast) markers and molecular mechanisms involved in mechanically-induced regulation of bone cell markers; including the type I collagen, osteocalcin, alkaline phosphatase, osteopontin, dentin matrix protein (DMP1), matrix extracellular phosphoglycoprotein (MEPE/OF45) bone morphogenetic proteins and homeobox genes, after stimulation of periodontal bone by application of controlled orthodontic forces. She is also involved in cell culture studies of immortalized bone cell lines from transgenic mice, subject to different components of mechanical stress.
She is a member of the American Dental Association and the American Society of Bone and Mineral Research.
Publications
1. Gluhak-Heinrich, J.,
Bonewald, L. F., MacDougall, M., Harris, S. E., and Pavlin, D. (2003). Mechanical
load stimulates dentin matrix protein 1 (DMP1) in osteocytes in vivo. J
Bone Min Res 18(5), 807-817.
2. Pavlin, D., Ramirez, L., and Gluhak-Heinrich, J. (2002). Effect of orthodontic mechanical loading in mouse on the number of cells and the expression of bone characteristic genes in cementoblasts: distinction from the osteoblast phenotype. Archives of Oral Biology (accepted for publication).
3. Pavlin, D., and Gluhak-Heinrich, J. (2001). Effect of mechanical loading on periodontal cells. Crit Rev Oral Biol Med 12, 414-424.
4. Knight, C., Simmons, T. T., Gluhak-Heinrich, J., Pavlin, D., Zeichner-David, M., and MacDougall, M. (2001). Cloning, characterization and tissue expression pattern of mouse Nma, a novel transmembrane protein. J Dent Res 80, 1895-1902.
5. Giambernardi, T. A., Sakaguchi, A. Y., Gluhak-Heinrich, J., Pavlin, D., Troyer, D., Rodeck, U., and Klebe, R. J. (2001). MMP-8 (collagenase-2), the first fibrillar collagenase expressed during development, is found in cells of neural crest origin and melanoma. Matrix Biology 20, 577-587.
6. Pavlin, D., Zadro, R., and Gluhak-Heinrich, J. (2001). Temporal pattern of stimulation of osteoblast-associated genes during mechanically-induced osteogenesis in vivo: Early responses of osteocalcin and type I collagen. Connective Tissue Research 42, 135-48.
7. Pavlin, D., Dove, S. B., Zadro, R., and Gluhak-Heinrich, J. (2000). Mechanical loading stimulates differentiation of periodontal osteoblasts in a mouse osteoinduction model: the effect on type I collagen and alkaline phosphatase. Calcif Tissue Int 67, 163-172.
8. Pavlin, D., Magness, M., Zadro, R., Goldman, E. S., and Gluhak-Heinrich, J. (2000). Orthodontically stressed periodontium of transgenic mouse as a model for studying mechanical response in bone: the effect on the number of osteoblasts. Clin Orthod Res 3, 55-66.
9. Gluhak J, Mais A, Mina M. Tenascin -C is assocated with early stages of chondrogenesis by chick mandibular ectomesenchymal cells in vivo and in vitro. Dev Dyn 1996;205:24-40.
10. Mina M, Gluhak J, Rodgers B. Downregulation of Msx-2 expression results in chondrogenesis in the medial region of the avian mandible. Conn Tissue Res 1996;35(1-4):79-84.
Abstracts:
1. Gluhak-Heinrich, J., Pavlin, D.,
Kotha, S. P., Bonewald, L. F., Schaffler, M. B., Harris, S. E. (2003). DMP1
expression pattern in osteocytes using the rat ulnae mechanical and fatigue
loading model-comparison to experimental and finite element strain analysis. J
Bone Min Res (accepted for 2003 ASMBR).
2. To, V. Q., Gluhak-Heinrich, J.,Jiang, J. X., Pavlin, D., (2002). Expression of Connexin 43 During Tooth Eruption in Mouse. (2003) J Dent Res: 82 Special Issue A: 37.
3. Gluhak-Heinrich, J., Pavlin, D., Bonewald, L. F., MacDougall, M., Harris, S. E. (2002). Increased dentin matrix protein 1 (DMP1) gene expression in osteocytes during mechanical load of bone. (2002). J Bone Min Res 17 (suppl1): S308.
4. Gluhak-Heinrich, J., Pavlin, D., Bonewald, L. F., MacDougall, M., Harris, S. E. (2002). Dentin matrix protein 1 (DMP1) is elevated in osteocytes in response to mechanical load in vivo. Third International Conference on Osteopontin, San Antonio, TX, May 10-12, 2002.
5. Pavlin, D., Goldman, E., and Gluhak-Heinrich, J. (2001). Effect of aging on mechanical stimulation of osteoblast-characteristic genes. J Dent Res 80: 697.
6. To, V. Q., Villareal, A., Gluhak-Heinrich, J., and Pavlin, D. (2001). The effect of fluid flow on the expression of osteoblast associated genes. J Dent Res 80: 243.
7. Giambernardi, T. A., Sakaguchi, A. Y., Rodeck, U., Steffensen, B., Pavlin, D., Gluhak, J., Troyer, D., and Klebe, R. J. (2000). MMP-8 expression in development and human melanoma. 10th Annual Symposium on Cancer Research in San Antonio.
8. Pavlin, D., Villarreal, A., and Gluhak, J. (2000). Mechanical response of bone sialoprotein and osteopontin gene in cementoblasts. J Dent Res 79, 423.
9. Gluhak-Heinrich, J., Villarreal, A., and Pavlin, D. (2000). Reciprocal regulation of osteopontin gene during mechanically induced bone formation and resrption. J Bone Min Res 14, S447.
10. Gluhak-Heinrich J, Villareal A, Pavlin D. Induction and time course of bone sialoprotein gene expression during differentiation of nechanically stimulated osteoblasts. J Bone Min Res 1999;14(suppl1):S477.
11. Gluhak J, Goldman E, Villarreal A, Ramirez L, Urias SE, Pavlin D. Early Induction of Alkaline Phosphatase Gene in Mechanically Stressed Periodontal Osteoblasts. J Dent Res 1999;78:500.
12. Knight C, Gluhak J, Pavlin D, MacDougall M. Temporal Spatial Expression Pattern of Mouse Nma During Odontogenesis. J Dent Res 1999;78:212.
13. Pavlin D, Zadro R, Goldman ES, Gluhak-Heinrich J. Distinct DNA regions of collagen 1 gene regulate constitutive expression and response to mechanical stress. J Bone Min Res 1999;14(suppl1):S194.
14. Ramirez L, Gluhak J, Urias SE, Goldman E, Pavlin D. Response of Osteoblast Marker Genes to Mechanical Stress in Acellular Cementum. J Dent Res 1999;78:500.
15. Urias SE, Gluhak J, Ramirez E, Goldman E, Pavlin D. Effect of Mechanical Stress on Bone Markers in Cellular Cementum. J Dent Res 1999;78:500.
16. Gluhak J, Ramirez L, Urias SE, Pavlin D. The time course of osteocalcin gene induction by mechanical stress in osteoblasts. J. Dental Research 1998;77(B):975.
17. Mina M, Upholt WB, Gluhak J. Expression of Dlx 5 in the avian mandibular arch. J. Dental Research 1998;77(A):185.
18. Pavlin D, Ramirez L, Urias SE, Gluhak J. The sequence of induction of bone marker genes in mechanically stressed periodontium. J. Dental Research 1998;77(B):1027.
19. Pavlin D, Binkley P, Gluhak J. Stimulation of osteocalcin gene expression in osteoblasts subject to mechanical stress. Bone and Mineral Research 1997;21 SI:429.
20. Pavlin D, Binkley P, Gluhak J, Nydegger J, Rosen AT, MacDougal. Vitamin D and PTH regulate bone markers in situ immortalized osteoblasts. Dental Res. 1997;76 SI:285.
21. Gluhak J, Mina M. Effects of Msx-2 antisense oligonucleotides on chondrogenesis of the avian mandibular ectomesenchyme. Northeast Regional Developmental Biology Conference 1996 (Woods Hole, Massachusetts).
22. Mina M, Gluhak J, Rogers B. Collagen in vitro. J. Dental Research 1996;76:408.
23. Mina M, Rodgers B, Gluhak J. Differential effects of FGFs on proliferation and chondrogenesis on the mandibular mesenchyme in vitro. J. Dental Research 1996;76:234.